137-48-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Nitrochlorobenzene-4-sulfomethyl amide is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Nitrochlorobenzene-4-sulfomethyl amide serves as an intermediate in the production of various agrochemicals. Its involvement in the synthesis process contributes to the creation of effective compounds for pest control and crop protection.
Used in Dye Industry:
2-Nitrochlorobenzene-4-sulfomethyl amide is also utilized as an intermediate in the dye industry. Its chemical properties make it suitable for the synthesis of a range of dyes with specific color characteristics and applications in various industries, such as textiles and plastics.

InChI:InChI=1/C7H7ClN2O4S/c1-9-15(13,14)5-2-3-6(8)7(4-5)10(11)12/h2-4,9H,1H3

Upstream product

• 97-08-5 3-nitro-4-chlorosulfonyl chloride 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 100375-34-6 3-Nitro-4-(4-chlor-phenylmercapto)-benzolsulfonsaeure-methylamid 
• 1766-16-1 4-Chloro-N-(dichloro-fluoro-methylsulfanyl)-N-methyl-3-nitro-benzenesulfonamide 
• 1351092-32-4 N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide 
• 1351092-89-1 4-chloro-N-methyl-3-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide 
• 41607-87-8 3-amino-4-chloro-N-methylbenzenesulfonamide 
• 100524-21-8 3-Nitro-4-amino-benzolsulfonsaeure-methylamid 
• 96-58-2 4-hydroxy-N-methyl-3-nitrobenzenesulfonamide 
• 107518-41-2 3-Nitro-4-phenoxy-benzolsulfonsaeure-methylamid 
• 68502-28-3 4-methylamino-3-nitro-benzenesulfonic acid methylamide 
• 93865-70-4 4-p-anisidino-3-nitro-benzenesulfonic acid methylamide 
• 93898-74-9 3-Nitro-4-<4-aethoxy-anilino>-benzolsulfonsaeure-methylamid 
• 101113-23-9 3-Nitro-4-(2,5-dimethyl-phenylmercapto)-benzolsulfonsaeure-methylamid 
• 43041-72-1 4-(dimethylamino)-N-methyl-3-nitrobenzene-1-sulfonamide 
• 106840-39-5 N-methyl-4-(methyloxy)-3-nitrobenzenesulfonamide 

Relevant academic research and scientific papers

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated necrosis that is critically dependent on glutathione peroxidase 4 (GPX4). It has been shown to contribute to liver and kidney ischemia reperfusion injury in mice. A chemical inhibitor discovered by high-throughput screening displayed inhibition of ferroptosis with nanomolar activity and was dubbed ferrostatin-1 (fer-1). Ferrostatins inhibit oxidative lipid damage, but suffer from inherent stability problems due to the presence of an ester moiety. This limits the application of these molecules in vivo, due to rapid hydrolysis of the ester into the inactive carboxylic acid. Previous studies highlighted the importance of the ethyl ester and suggested steric modifications of the ester for generating improved molecules. In this study, we report the synthesis of novel ferroptosis inhibitors containing amide and sulfonamide moieties with improved stability, single digit nanomolar antiferroptotic activity, and good ADME properties suitable for application in in vivo disease models.

3,4-DIAMINOBENZENESULFONAMIDE DERIVATIVES FOR INHIBITING CELL DEATH

The present invention relates to a novel class of compounds having the structure of formula (I) and pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof. These compounds inhibit or reduce the non-apoptotic cell death forms ferroptosis and/or oxytosis rendering them useful for the treatment of various conditions disclosed herein.

COMPOUNDS AND METHODS

Disclosed are compounds having the Formula (I), wherein X, Y, Z, R1, R2 and R3 are as defined herein, and methods of making and using the same.

QUINAZOLINE COMPOUNDS

Disclosed are compounds having the formula: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein, and methods of making and using the same.

COMPOUNDS AND METHODS

Disclosed are compounds having the formula (I): wherein R1, R2, R3, R4, R5, and R6 are as defined herein, and methods of making and using the same.