1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone

Base Information

Chemical Name:1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone
CAS No.:152775-74-1
Molecular Formula:C₁₈H₂₁N₅O₃
Molecular Weight:355.396
Hs Code.:

Synonyms:1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone

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Chemical Property of 1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone

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Technology Process of 1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone

There total 10 articles about 1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

: 75-16-1
methylmagnesium bromide

: 152775-55-8
N,O-dimethyl-N-hydroxy-5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxamide

: 152775-74-1
1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone

Guidance literature:: In tetrahydrofuran; diethyl ether; for 1h;
DOI:10.1021/jm00074a004

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 152775-74-1
1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

2: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

3: 72.3 percent / LiOH, H₂O / ethanol / a) RT, 12 h, b) reflux, 2 h

4: 1.) 1,1'-carbonyldiimidazole / 1.) CHCl₃, 2.) CHCl₃, 12 h

5: 93.5 percent / tetrahydrofuran; diethyl ether / 1 h

With lithium hydroxide; water; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform;
DOI:10.1021/jm00074a004

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 152775-74-1
1-<5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolyl>ethanone

Guidance literature:: Multi-step reaction with 9 steps

1: 93.2 percent / K₂CO₃ / acetone / 18 h / Heating

2: 62 percent / NaN₃, NH₄Cl / dimethylformamide / 24 h / 110 °C

3: 67 percent / K₂CO₃ / acetonitrile / 1 h / Heating

4: 96 percent / BBr₃ / CH₂Cl₂

5: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

6: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

7: 72.3 percent / LiOH, H₂O / ethanol / a) RT, 12 h, b) reflux, 2 h

8: 1.) 1,1'-carbonyldiimidazole / 1.) CHCl₃, 2.) CHCl₃, 12 h

9: 93.5 percent / tetrahydrofuran; diethyl ether / 1 h

With lithium hydroxide; sodium azide; water; boron tribromide; potassium carbonate; ammonium chloride; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00074a004