4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline

Base Information

Chemical Name:4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline
CAS No.:1207089-25-5
Molecular Formula:C₁₃H₁₁F₇N₄
Molecular Weight:356.246
Hs Code.:

Synonyms:4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline

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Chemical Property of 4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline

Chemical Property:

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Technology Process of 4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline

There total 5 articles about 4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-45-6
Chlorodifluoromethane

: 1207089-21-1
5-(3-methyl-4-nitrobenzyl)-3-(pentafluoroethyl)-1H-1,2,4-triazole

: 1207089-25-5
4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline

: 1207089-24-4
4-{[1-(difluoromethyl)-3-(pentafluoroethyl)-1H-1,2,4-triazol-5-yl]methyl}-2-methylaniline

Guidance literature:: Chlorodifluoromethane; 5-(3-methyl-4-nitrobenzyl)-3-(pentafluoroethyl)-1H-1,2,4-triazole; With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Sealed tube;

With titanium(III) chloride; ammonium acetate; water; In acetone; at 20 ℃; for 8h;

Reference yield:

: 75-45-6
Chlorodifluoromethane

: 1207089-21-1
3-(3-methyl-4-nitrobenzyl)-5-(pentafluoroethyl)-1,2,4-triazole

: 1207089-25-5
4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline

: 1207089-24-4
4-{[1-(difluoromethyl)-3-(pentafluoroethyl)-1H-1,2,4-triazol-5-yl]methyl}-2-methylaniline

Guidance literature:: Chlorodifluoromethane; 3-(3-methyl-4-nitrobenzyl)-5-(pentafluoroethyl)-1,2,4-triazole; With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 12h;

With titanium(III) chloride; ammonium acetate; In acetone;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 119713-11-0
(3-methyl-4-nitrophenyl)acetonitrile

: 1207089-25-5
4-{[1-(difluoromethyl)-5-(pentafluoroethyl)-1H-1,2,4-triazol-3-yl]methyl}-2-methylaniline

: 1207089-24-4
4-{[1-(difluoromethyl)-3-(pentafluoroethyl)-1H-1,2,4-triazol-5-yl]methyl}-2-methylaniline

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; triethylamine / methanol / 8 h / 20 °C

2: toluene / 4.5 h / Reflux

3: hydrazine hydrate / methanol / 48 h

4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C

With hydrazine hydrate; hydroxylamine hydrochloride; potassium carbonate; triethylamine; In methanol; N,N-dimethyl-formamide; toluene;