N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide

Base Information

Chemical Name:N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide
CAS No.:1352714-79-4
Molecular Formula:C₅₀H₄₈ClNO₇
Molecular Weight:810.387
Hs Code.:

Synonyms:N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide

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Chemical Property of N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide

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Technology Process of N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide

There total 11 articles about N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1260242-59-8
1-amino-3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)propan-2-one hydrochloride

: 65-85-0,8013-63-6
benzoic acid

: 1352714-79-4
N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1260242-00-9
(2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-(benzyloxymethyl)-6-(3-(bromomethyl)-4-chlorophenyl)-tetrahydro-2H-pyran

: 1352714-79-4
N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol; water / 15 h / Reflux

2.1: sodium hydroxide; water / ethanol / Reflux

2.2: 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5.25 h / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane; diethyl ether / 3 h / -30 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: hydrogen bromide / dichloromethane; diethyl ether; water / 0.5 h / 0 °C

6.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / dichloromethane; ethanol / 3.5 h / 0 - 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; water; hydrogen bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; N,N-dimethyl-formamide; In diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1225430-39-6
2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)acetonitrile

: 1352714-79-4
N-(3-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-2-oxopropyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; water / ethanol / Reflux

1.2: 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5.25 h / 0 - 20 °C / Inert atmosphere

3.1: dichloromethane; diethyl ether / 3 h / -30 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: hydrogen bromide / dichloromethane; diethyl ether; water / 0.5 h / 0 °C

5.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride; water / dichloromethane; ethanol / 3.5 h / 0 - 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; water; hydrogen bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; N,N-dimethyl-formamide; In diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;