2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene

Base Information

• Chemical Name: 2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene
• CAS No.: 153907-93-8
• Molecular Formula: C₁₇H₁₃F₃N₂O₃
• Molecular Weight: 350.297
• Mol file: 153907-93-8.mol

Synonyms:2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene

Chemical Property of 2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene

There total 3 articles about 2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(trifluoroacetylamino)phenyl]ethanol (115166-92-2) → 2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene (153907-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / -78 - 20 °C

2: 1.) NaH, 15-crown-5 / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h

With 15-crown-5; sodium hydride; Dess-Martin periodane; In dichloromethane;

DOI:10.1021/ja00081a008

Reference yield:

2-(4'-aminophenyl)ethyl alcohol (104-10-9) → 2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene (153907-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

2: 84 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / -78 - 20 °C

3: 1.) NaH, 15-crown-5 / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h

With 15-crown-5; sodium hydride; Dess-Martin periodane; triethylamine; In dichloromethane;

DOI:10.1021/ja00081a008

Reference yield:

diethyl p-nitrobenzylphosphonate (2609-49-6) + 2-<4-<(trifluoroacetyl)amino>phenyl>acetaldehyde (153907-92-7) → 2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene (153907-93-8)

Guidance literature:

With 15-crown-5; sodium hydride; Yield given. Multistep reaction; 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h;

DOI:10.1021/ja00081a008

upstream raw materials:

diethyl p-nitrobenzylphosphonate

2-<4-<(trifluoroacetyl)amino>phenyl>acetaldehyde

2-[4-(trifluoroacetylamino)phenyl]ethanol

2-(4'-aminophenyl)ethyl alcohol