7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine
CAS No.:1285456-65-6
Molecular Formula:C₁₆H₁₄ClF₂N₃O
Molecular Weight:337.756
Hs Code.:

Synonyms:7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine

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Technology Process of 7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine

There total 3 articles about 7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2375-76-0
1-chloro-1,1-difluoropentane-2,4-dione

: 88945-41-9
N-(Cyanmethyl)formimidsaeure-methylester

: 2393-23-9
4-methoxy-benzylamine

: 1285456-65-6
7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: N-(Cyanmethyl)formimidsaeure-methylester; 4-methoxy-benzylamine; In dichloromethane; for 1.33333h; Inert atmosphere; Reflux;

1-chloro-1,1-difluoropentane-2,4-dione; In dichloromethane; at 20 ℃; Reflux;
DOI:10.1021/jo102579g

Reference yield:

: 2375-76-0
1-chloro-1,1-difluoropentane-2,4-dione

: 3-(4-methoxybenzyl)-3H-imidazol-4-ylamine

: 1285456-65-6
7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: In dichloromethane; for 2h; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.085

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 1285456-65-6
7-[chloro(difluoro)methyl]-3-(4-methoxybenzyl)-5-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / Reflux

2: dichloromethane / 2 h / Reflux; Inert atmosphere

With acetic acid; In dichloromethane;
DOI:10.1016/j.tet.2011.05.085