Tert-butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate

Base Information

Chemical Name:Tert-butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate
CAS No.:725228-52-4
Molecular Formula:C₃₀H₃₁FN₂O₄
Molecular Weight:502.586
Hs Code.:
DSSTox Substance ID:DTXSID10587377
Wikidata:Q82479784
Mol file:725228-52-4.mol

Synonyms:725228-52-4;tert-butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate;tert-butyl N-[[3-[1-[5-[2-(2-fluorophenyl)ethynyl]furan-2-carbonyl]piperidin-4-yl]phenyl]methyl]carbamate;SCHEMBL302010;DTXSID10587377;KQYRKAUORDFEOC-UHFFFAOYSA-N;(3-{1-[5-(2-fluoro-phenylethynyl)-furan-2-carbonyl]-piperidin-4-yl}-benzyl)-carbamic acid tert-butyl ester;(3-{1-[5-(2-Fluorophenylethynyl)furan-2-carbonyl]-piperidin-4-yl}benzyl)carbamic acid tert-butyl ester;(3-{1-[5-(2-fluorophenylethynyl)furan-2-carbonyl]piperidin-4-yl}benzyl)-carbamic acid tert-butyl ester;4-[3-(tert-Butoxycarbonylaminomethyl)phenyl]-1-[5-(2-fluorophenylethynyl)-2-furanoyl]piperidine;tert-Butyl (3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzyl)carbamate;tert-Butyl {[3-(1-{5-[(2-fluorophenyl)ethynyl]furan-2-carbonyl}piperidin-4-yl)phenyl]methyl}carbamate

Suppliers and Price of Tert-butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate 95%
5g
$ 4588.00

Matrix Scientific
tert-Butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate 95%
1g
$ 2709.00

Total 2 raw suppliers

Chemical Property of Tert-butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:502.22678564
Heavy Atom Count:37
Complexity:851

Purity/Quality:

95%-98% ^*data from raw suppliers

tert-Butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC1=CC(=CC=C1)C2CCN(CC2)C(=O)C3=CC=C(O3)C#CC4=CC=CC=C4F

Technology Process of Tert-butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate

There total 2 articles about Tert-butyl 3-(1-(5-((2-fluorophenyl)ethynyl)furan-2-carbonyl)piperidin-4-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 725228-53-5
5-(2-fluoro-phenylethynyl)-furan-2-carbonyl chloride

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

: 725228-52-4
(3-{1-[5-(2-fluorophenylethynyl)-furan-2-carbonyl]-piperidin-4-yl}-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 8 - 12 ℃; for 4h;

Reference yield:

: 864069-20-5
4-[3-(tert-butoxycarbonylaminomethyl)phenyl]-1-[5-bromo-2-furanoyl]piperidine

: 766-49-4
(2-fluorophenyl)acetylene

: 725228-52-4
(3-{1-[5-(2-fluorophenylethynyl)-furan-2-carbonyl]-piperidin-4-yl}-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: 4-[3-(tert-butoxycarbonylaminomethyl)phenyl]-1-[5-bromo-2-furanoyl]piperidine; (2-fluorophenyl)acetylene; With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; for 1h; Heating / reflux;

With 2,4,6-trimereaptotriazine, trisodium salt, nonahydrate; In tetrahydrofuran; methanol; water; for 1h; Heating / reflux;