17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5⁽¹⁰⁾,16-tetraene

Base Information

Chemical Name:17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5⁽¹⁰⁾,16-tetraene
CAS No.:897664-64-1
Molecular Formula:C₃₄H₃₂O₂S
Molecular Weight:504.693
Hs Code.:

17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5<sup>(10)</sup>,16-tetraene

Synonyms:17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5⁽¹⁰⁾,16-tetraene

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Chemical Property of 17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5⁽¹⁰⁾,16-tetraene

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Technology Process of 17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5⁽¹⁰⁾,16-tetraene

There total 2 articles about 17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5⁽¹⁰⁾,16-tetraene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 897664-60-7
3-benzyloxy-16-tert-butoxymethylene-estra-1,3,5⁽¹⁰⁾-trien-1-7-one

: 95-15-8,11095-43-5
Benzo[b]thiophene

: 897664-64-1
17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5⁽¹⁰⁾,16-tetraene

Guidance literature:: Benzo[b]thiophene; With n-butyllithium; In diethyl ether; pentane; at -78 - 0 ℃; for 1.5h;

3-benzyloxy-16-tert-butoxymethylene-estra-1,3,5⁽¹⁰⁾-trien-1-7-one; In tetrahydrofuran; diethyl ether; pentane; at 0 ℃; for 5h;

With water; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; pentane; for 25h;
DOI:10.1016/j.steroids.2005.06.001

Reference yield:

: 444196-21-8
16-hydroxymethylene-3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

: 897664-64-1
17-(benzothien-2'-yl)-3-benzyloxy-16-formyl-estra-1,3,5⁽¹⁰⁾,16-tetraene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / p-TsOH*H₂O / benzene / Heating

2.1: n-butyllithium / pentane; diethyl ether / 1.5 h / -78 - 0 °C

2.2: diethyl ether; tetrahydrofuran; pentane / 5 h / 0 °C

2.3: 85 percent / p-tolueneusulfonic acid; water / diethyl ether; tetrahydrofuran; pentane / 25 h

With n-butyllithium; toluene-4-sulfonic acid; In diethyl ether; pentane; benzene;
DOI:10.1016/j.steroids.2005.06.001