2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate
CAS No.:213686-00-1
Molecular Formula:C₁₈H₂₆N₂O₅S
Molecular Weight:382.481
Hs Code.:

Synonyms:2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate

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Chemical Property of 2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate

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Technology Process of 2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate

There total 4 articles about 2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 98-59-9
p-toluenesulfonyl chloride

: 540-51-2
2-bromoethanol

: 213686-00-1
2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate

Guidance literature:: (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere; Sealed tube;

2-bromoethanol; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 4h; Inert atmosphere; Sealed tube;

p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 2h; Inert atmosphere; Sealed tube;

Reference yield:

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 213686-00-1
2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi / tetrahydrofuran / 8 h / -78 °C

2: LiAlH₄ / tetrahydrofuran / -20 °C

3: pyridine / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; pyridine; 1: Carboxylation / 2: Reduction / 3: Tosylation;
DOI:10.1016/S0040-4020(98)00492-X

Reference yield:

: 213686-01-2,1415566-75-4
ethyl-(3S,6R)-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazin-6-yl-acetate

: 213686-00-1
2-[(2R,5S)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / -20 °C

2: pyridine / 0 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; pyridine; 1: Reduction / 2: Tosylation;
DOI:10.1016/S0040-4020(98)00492-X