4-(4-CHLOROPHENOXY)-2 CHLORO PHENYL ETHANONE

Base Information

• Chemical Name: 4-(4-CHLOROPHENOXY)-2 CHLORO PHENYL ETHANONE
• CAS No.: 13221-80-2
• Molecular Formula: C14H10Cl2O2
• Molecular Weight: 281.138
• Hs Code.: 2914700090
• Mol file: 13221-80-2.mol

Synonyms:Acetophenone,2-chloro-4'-(p-chlorophenoxy)- (7CI,8CI);4-(Chloroacetyl)-4'-chlorodiphenylether;2-Chloro-1-[4-(4-chlorophenoxy)phenyl]ethanone;4-(4-Chlorophenoxy)-2-chlorophenylethanone;

Chemical Property of 4-(4-CHLOROPHENOXY)-2 CHLORO PHENYL ETHANONE

Chemical Property:

• Boiling Point: 401.5 °C at 760 mmHg
• Flash Point: 163.6 °C
• PSA: 26.30000
• Density: 1.308 g/cm³
• LogP: 4.55380

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-1-(4-(4-chlorophenoxy)phenyl)ethan-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-CHLOROPHENOXY)-2 CHLORO PHENYL ETHANONE

There total 7 articles about 4-(4-CHLOROPHENOXY)-2 CHLORO PHENYL ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

4-chlorodiphenyl ether (7005-72-3) + chloroacetyl chloride (79-04-9) → 2-chloro-1-[4-(4-chlorophenoxy)phenyl]ethanone (13221-80-2)

Guidance literature:

With aluminium trichloride; In carbon disulfide; 1.) r.t., 30 min; 2.) reflux, 1 h;

Reference yield:

1-[4-(4-chlorophenoxy)phenyl]ethanone (41150-48-5) → 2-chloro-1-[4-(4-chlorophenoxy)phenyl]ethanone (13221-80-2)

Guidance literature:

With sulfuryl dichloride; In methanol; dichloromethane; at 20 ℃;

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 2-chloro-1-[4-(4-chlorophenoxy)phenyl]ethanone (13221-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / CuCl₂ / pyridine / 10 h / Heating

2: 70 percent / AlCl₃ / CS₂

With aluminium trichloride; copper dichloride; In pyridine; carbon disulfide;

DOI:10.1248/cpb.32.3066

upstream raw materials:

4-chlorodiphenyl ether

chloroacetyl chloride

bromobenzene

sodium 4-chlorophenolate

Downstream raw materials:

ethyl trans-3-<4-(4-chlorophenoxy)benzoyl>glycidate

1-chloro-2-[4-(4-chlorophenoxy)phenyl]pent-3-yn-2-ol

trans-3-<4-(4-chlorophenoxy)benzoyl>glycidic acid

cis-3-<4-(4-chlorophenoxy)benzoyl>glycidic acid

Refernces

• 1、 Tomisawa,Kameo,Goi,Sota. "Studies on hypolipidemic agents. I. 3-benzoylglycidic acid derivatives". . p. 3066 - 3074. Retrieved 2007/10/02.
• 2、 CAVALLINI,MASSARANI,NARDI,MAURI,TENCONI,PACCHIANO,MANTEGAZZA. "ANTIBACTERIAL AGENTS. SOME NEW HALOMETHYL ARYL KETONES.". . p. 573 - 578. Retrieved 2007/10/13.