phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate

Base Information

• Chemical Name: phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate
• CAS No.: 1449763-31-8
• Molecular Formula: C₃₁H₃₂FN₃O₅
• Molecular Weight: 545.611
• Mol file: 1449763-31-8.mol

Synonyms:phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate

Chemical Property of phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate

There total 9 articles about phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.1%

3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline (960299-69-8) + phenyl chloroformate (1885-14-9) → phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate (1449763-31-8)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.bmc.2013.06.026

Reference yield:

1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one (1160707-44-7) → phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate (1449763-31-8)

Guidance literature:

Multi-step reaction with 7 steps

1: toluene / 110 °C

2: iron / acetic acid / 2 h / 40 - 80 °C

3: acetonitrile / 8 h / 25 - 80 °C

4: trichlorophosphate / acetonitrile / Reflux

5: chlorobenzene / 20 h / 140 °C

6: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

7: potassium carbonate / acetone / 3 h / 0 - 20 °C

With hydrogenchloride; iron; potassium carbonate; trichlorophosphate; In ethanol; water; acetic acid; chlorobenzene; acetone; toluene; acetonitrile;

DOI:10.1016/j.bmc.2013.06.026

Reference yield:

4-(3-chloropropoxy)-3-methoxyacetophenone (58113-30-7) → phenyl 3-fluoro-4-(6-methoxy-7-(3-(piperdine-1-yl)propoxy)-quinolin-4-yloxy)phenylcarbamate (1449763-31-8)

Guidance literature:

Multi-step reaction with 8 steps

1: nitric acid / dichloromethane / 2 h / -10 °C

2: toluene / 110 °C

3: iron / acetic acid / 2 h / 40 - 80 °C

4: acetonitrile / 8 h / 25 - 80 °C

5: trichlorophosphate / acetonitrile / Reflux

6: chlorobenzene / 20 h / 140 °C

7: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

8: potassium carbonate / acetone / 3 h / 0 - 20 °C

With hydrogenchloride; nitric acid; iron; potassium carbonate; trichlorophosphate; In ethanol; dichloromethane; water; acetic acid; chlorobenzene; acetone; toluene; acetonitrile;

DOI:10.1016/j.bmc.2013.06.026

upstream raw materials:

4-(3-chloropropoxy)-3-methoxyacetophenone

1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

3-fluoro-4-((6-methoxy-7-(3-(piperdine-1-yl)propoxy)quinolin-4-yl)oxy)aniline

phenyl chloroformate

Downstream raw materials:

(E)-N⁴-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinoline-4-yloxy)phenyl)-N¹-(benzylidene)semicarbazide

(E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-chlorobenzylidene)semicarbazide

(E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(3,4-difluorobenzylidene)semicarbazide

(E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2-fluorobenzylidene)semicarbazide