(R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

Base Information

Chemical Name:(R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine
CAS No.:501085-76-3
Molecular Formula:C₃₀H₃₀N₂O
Molecular Weight:434.581
Hs Code.:

Synonyms:(R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

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Chemical Property of (R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

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Technology Process of (R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

There total 6 articles about (R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501085-74-1
(RS)-2-[4-(benzyloxy)benzyl]-N-methyl-N-[(R)-1-(naphthalen-1-yl)ethyl]propanethioamide

: 501085-75-2
(S)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

: 501085-76-3
(R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

Guidance literature:: (RS)-2-[4-(benzyloxy)benzyl]-N-methyl-N-[(R)-1-(naphthalen-1-yl)ethyl]propanethioamide; With N,N-dimethyl-formamide; In dichloromethane; toluene; at 0 ℃; for 0.416667h;

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; at 0 ℃; for 0.25h;

With sodium azide; In tetrahydrofuran; at 20 ℃; for 7h;
DOI:10.1002/1522-2675(200210)85:10<3422::AID-HLCA3422>3.0.CO;2-N

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 501085-76-3
(R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / NaH / dimethylformamide / 6 h / 20 °C

2.1: 100 percent / PBr₃ / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / 0 °C

3.2: 92 percent / tetrahydrofuran; heptane; ethylbenzene / 1.58 h / 0 - 5 °C

4.1: 78 percent / Lawesson reagent / toluene / 3.5 h / 125 °C

5.1: DMF; COCl₂ / CH₂Cl₂; toluene / 0.42 h / 0 °C

5.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.25 h / 0 °C

5.3: NaN₃ / tetrahydrofuran / 7 h / 20 °C

With Lawessons reagent; phosphorus tribromide; sodium hydride; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide; toluene;
DOI:10.1002/1522-2675(200210)85:10<3422::AID-HLCA3422>3.0.CO;2-N

Reference yield:

: 836-43-1
4-benzyloxybenzyl alcohol

: 501085-76-3
(R)-2-[4-(benzyloxy)benzyl]-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / PBr₃ / CH₂Cl₂ / 2 h / 0 - 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / 0 °C

2.2: 92 percent / tetrahydrofuran; heptane; ethylbenzene / 1.58 h / 0 - 5 °C

3.1: 78 percent / Lawesson reagent / toluene / 3.5 h / 125 °C

4.1: DMF; COCl₂ / CH₂Cl₂; toluene / 0.42 h / 0 °C

4.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.25 h / 0 °C

4.3: NaN₃ / tetrahydrofuran / 7 h / 20 °C

With Lawessons reagent; phosphorus tribromide; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; toluene;
DOI:10.1002/1522-2675(200210)85:10<3422::AID-HLCA3422>3.0.CO;2-N