3-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER
• CAS No.: 13148-83-9
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.181
• Hs Code.: 2918300090
• Mol file: 13148-83-9.mol

Synonyms:3-(Methoxycarbonyl)cyclohexanone;3-Oxocyclohexanecarboxylic acid methyl ester; Methyl3-oxocyclohexanecarboxylate

Chemical Property of 3-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 121-123 °C(Press: 16 Torr)
• PSA: 43.37000
• Density: 1.111±0.06 g/cm3(Predicted)
• LogP: 0.91870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95-99% ^*data from raw suppliers

3-Oxo-CyclohexanecarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER

There total 41 articles about 3-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-hydroxycyclohexanecarboxylate (37722-82-0) → 3-oxo-cyclohexanecarboxylic acid methyl ester (21531-47-5,49543-02-4,13148-83-9,1236384-30-7)

Guidance literature:

With sodium bromate; ruthenium (IV) oxide monohydrate; In diethyl ether; water; at 30 ℃; for 1h; Cooling with ice;

Reference yield: 100.0%

sodium methylate (124-41-4) + (1R,6R)-7,7-Dichloro-bicyclo[4.1.0]heptan-2-one → 3-oxo-cyclohexanecarboxylic acid methyl ester (21531-47-5,49543-02-4,13148-83-9,1236384-30-7)

Guidance literature:

In methanol; at 18 ℃; for 1h;

DOI:10.1039/c39830001453

Reference yield: 92.0%

methyl 1-bromomethyl-2-oxocyclopentane-1-carboxylate (107986-99-2) → 3-oxo-cyclohexanecarboxylic acid methyl ester (21531-47-5,49543-02-4,13148-83-9,1236384-30-7) + dimethyl 1,1'-(ethane-1,2-diyl)bis(2-oxocyclopentane-1-carboxylate)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In N,N-dimethyl-formamide; Concentration; Mechanism; Electrochemical reaction;

DOI:10.1149/2.0491414jes

upstream raw materials:

(+/-)-methyl cis-3-hydroxycyclohexanecarboxylate

methanol

(RS)-3-oxocyclohexanecarbonitrile

2,2-Dimethyl-5-oxa-2-sila-bicyclo[5.3.1]undec-1⁽¹⁰⁾-en-6-one

Downstream raw materials:

methyl (1R,3S)-3-hydroxycyclohexane-1-carboxylate

methyl (1S,3R)-3-hydroxycyclohexane-1-carboxylate

methyl (1S,3S)-3-hydroxycyclohexane-1-carboxylate

3-oxo-cyclohexanecarboxylic acid

Refernces

• 1、 -. "DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES". Page/Page column 65-66. . Retrieved 2019/11/28.
• 2、 Deguchi, Masato,Fujiya, Akitoshi,Yamaguchi, Eiji,Tada, Norihiro,Uno, Bunji,Itoh, Akichika. "Organic dye-catalyzed radical ring expansion reaction". . p. 15825 - 15830. Retrieved 2018/05/04.