N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide

Base Information

Chemical Name:N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide
CAS No.:1618635-10-1
Molecular Formula:C₃₂H₃₄BrN₃O₄
Molecular Weight:604.544
Hs Code.:

Synonyms:N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide

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Chemical Property of N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide

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Technology Process of N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide

There total 3 articles about N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 110-91-8,99108-56-2
morpholine

: 1407513-02-3
(S)-N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-1-(4-methoxyphenyl)ethanamine

: 79-04-9
chloroacetyl chloride

: 1618635-10-1
N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide

Guidance literature:: (S)-N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-1-(4-methoxyphenyl)ethanamine; chloroacetyl chloride; With triethylamine; In dichloromethane; at -5 - 20 ℃; for 3h;

morpholine; With potassium carbonate; In acetonitrile; at 75 ℃; for 8h;
DOI:10.1002/ejoc.201400135

Reference yield:

: 1189178-87-7
6-bromo-3-[chloro(phenyl)methyl]-2-methoxyquinoline

: 1618635-10-1
N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; sodium iodide / acetonitrile / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 3 h / -5 - 20 °C

2.2: 8 h / 75 °C

With potassium carbonate; triethylamine; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201400135

Reference yield:

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
(S)-1-(4-methoxyphenyl)ethylamine

: 1618635-10-1
N-[(S)-(6-bromo-2-methoxy-3-quinolinyl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-morpholinoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; sodium iodide / acetonitrile / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 3 h / -5 - 20 °C

2.2: 8 h / 75 °C

With potassium carbonate; triethylamine; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201400135