(S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

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Chemical Name:(S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride
CAS No.:82247-65-2
Molecular Formula:C₂₇H₃₅N₇O₅*2ClH
Molecular Weight:610.541
Hs Code.:

(S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

Synonyms:(S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

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Chemical Property of (S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

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Technology Process of (S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

There total 4 articles about (S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 82265-54-1
(S)-2-[(S)-1-({[(S)-1-(Hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 82247-65-2
(S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 2h;
DOI:10.1021/ja00381a006

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 82247-65-2
(S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / dicyclohexycarbodiimide, N-hydroxybenzotriazole, N-methylmorpholine

2: 81 percent / hydrazine monohydrate / methanol / 2 h / 40 °C

3: 80 percent / 2N HCl / dioxane / 2 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol;
DOI:10.1021/ja00381a006

Reference yield:

: 82265-53-0
(S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 82247-65-2
(S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / hydrazine monohydrate / methanol / 2 h / 40 °C

2: 80 percent / 2N HCl / dioxane / 2 h

With hydrogenchloride; hydrazine hydrate; In 1,4-dioxane; methanol;
DOI:10.1021/ja00381a006