(R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine

Base Information

• Chemical Name: (R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine
• CAS No.: 450368-82-8
• Molecular Formula: C₂₅H₂₉N₃O₄S
• Molecular Weight: 467.589
• Mol file: 450368-82-8.mol

Synonyms:(R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine

Chemical Property of (R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine

There total 6 articles about (R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R,R)-N-tert-butoxycarbonyl-N'-(4-nitrophenylsulfonyl)-1,2-diphenylethylenediamine (450368-81-7) → (R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine (450368-82-8)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jo0257795

Reference yield:

(R,R)-1,2-diphenylethylenediamine (35132-20-8) → (R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine (450368-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / NEt₃ / CH₂Cl₂ / 20 °C

2: 99 percent / DIPEA / CH₂Cl₂ / 24 h / 20 °C

3: 99 percent / ammonium formate / Pd/C / methanol / 1 h / 20 °C

With ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jo0257795

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → (R,R)-N-tert-butoxycarbonyl-N'-(4-aminophenylsulfonyl)-1,2-diphenylethylenediamine (450368-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / NEt₃ / CH₂Cl₂ / 20 °C

2: 99 percent / DIPEA / CH₂Cl₂ / 24 h / 20 °C

3: 99 percent / ammonium formate / Pd/C / methanol / 1 h / 20 °C

With ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jo0257795

upstream raw materials:

(R,R)-N-tert-butoxycarbonyl-N'-(4-nitrophenylsulfonyl)-1,2-diphenylethylenediamine

di-tert-butyl dicarbonate

(R,R)-1,2-diphenylethylenediamine

4-Nitrobenzenesulfonyl chloride

Downstream raw materials:

{(1R,2R)-2-[4-(2-Amino-acetylamino)-benzenesulfonylamino]-1,2-diphenyl-ethyl}-carbamic acid tert-butyl ester

{(1R,2R)-2-[4-(2-Benzyloxycarbonylamino-acetylamino)-benzenesulfonylamino]-1,2-diphenyl-ethyl}-carbamic acid tert-butyl ester