tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate

Base Information

• Chemical Name: tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate
• CAS No.: 1388891-79-9
• Molecular Formula: C₂₂H₃₁N₃O₃S
• Molecular Weight: 417.572

Synonyms:tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate

Chemical Property of tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate

There total 3 articles about tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-81-3) + ethyl iodide (75-03-6) → tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate (1388891-79-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

trans-tert-butyl 4-hydroxycyclohexylcarbamate (111300-06-2) → tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate (1388891-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine (300816-22-2) → tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate (1388891-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

trans-tert-butyl 4-hydroxycyclohexylcarbamate

tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate

ethyl iodide

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine

Downstream raw materials:

(1r,4r)-N-benzyl-N-ethyl-4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexan-1-amine

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