tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

Base Information

Chemical Name:tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate
CAS No.:1449410-50-7
Molecular Formula:C₃₁H₃₆ClF₄N₇O₄
Molecular Weight:682.118
Hs Code.:

tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

Synonyms:tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

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Chemical Property of tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

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Technology Process of tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

There total 5 articles about tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1449410-49-4
4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

: 292606-35-0
N-tert-butyloxycarbonyl-2,2-dimethyl-1,3-propanediamine

: 1449410-50-7
tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1449410-47-2
methyl 4-{[4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoate

: 1449410-50-7
tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 80 °C

2: lithium hydroxide; water / tetrahydrofuran / 7 h / 80 °C

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1449410-48-3
methyl 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoate

: 1449410-50-7
tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran / 7 h / 80 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane;