4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide

Base Information

Chemical Name:4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide
CAS No.:1449398-08-6
Molecular Formula:C₃₂H₃₅ClF₄N₈O₄
Molecular Weight:707.128
Hs Code.:

4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide

Synonyms:4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide

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Chemical Property of 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide

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Technology Process of 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide

There total 7 articles about 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 49791-37-9
2-oxo-2-(pyrrolidin-1-yl)acetic acid

: 1449410-51-8
N-(3-amino-2,2-dimethylpropyl)-4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamide

: 1449398-08-6
4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1449410-49-4
4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

: 1449398-08-6
4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1449410-50-7
tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate

: 1449398-08-6
4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;