4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

Base Information

Chemical Name:4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid
CAS No.:1449410-49-4
Molecular Formula:C₂₁H₁₆ClF₄N₅O₃
Molecular Weight:497.836
Hs Code.:

Synonyms:4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

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Chemical Property of 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

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Technology Process of 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

There total 4 articles about 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449410-48-3
methyl 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoate

: 1449410-49-4
4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 80 ℃; for 7h;

Reference yield:

: 1449410-47-2
methyl 4-{[4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoate

: 1449410-49-4
4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 80 °C

2: lithium hydroxide; water / tetrahydrofuran / 7 h / 80 °C

With water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran;

Reference yield:

: 185677-00-3
2,4-dichloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine

: 1449410-49-4
4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 80 °C

3: lithium hydroxide; water / tetrahydrofuran / 7 h / 80 °C

With water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran;