(R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide

Base Information

Chemical Name:(R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide
CAS No.:1608484-84-9
Molecular Formula:C₂₈H₃₃BrN₂O₂S
Molecular Weight:541.552
Hs Code.:

Synonyms:(R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide

Suppliers and Price of (R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide

There total 4 articles about (R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (R)-N-benzyl-N-(2-bromophenyl)-4-(1,1-dimethylethylsulfinamido)butanamide

: 100-39-0
benzyl bromide

: 1608484-84-9
(R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide

Guidance literature:: (R)-N-benzyl-N-(2-bromophenyl)-4-(1,1-dimethylethylsulfinamido)butanamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 0 - 20 ℃; for 14h; Inert atmosphere;
DOI:10.1039/c5cc05378a

Reference yield:

: 1380585-86-3
N-benzyl-N-(2-bromophenyl)-4-hydroxybutanamide

: 1608484-84-9
(R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane / dichloromethane / 6 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 12 h / 60 °C

3.1: sodium tetrahydroborate / methanol / 4.5 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 14 h / 0 - 20 °C / Inert atmosphere

With titanium(IV) tetraethanolate; sodium tetrahydroborate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c5cc05378a

Reference yield:

: 615-36-1
2-bromoaniline

: 1608484-84-9
(R)-N-benzyl-4-(N-benzyl-2-methylpropan-2-ylsulfinamido)-N-(2-bromophenyl)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trimethylaluminum / toluene / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: caesium carbonate / acetonitrile; N,N-dimethyl-formamide / 8 h / 0 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 6 h / 20 °C

4.1: titanium(IV) tetraethanolate / tetrahydrofuran / 12 h / 60 °C

5.1: sodium tetrahydroborate / methanol / 4.5 h / 0 °C

6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

6.2: 14 h / 0 - 20 °C / Inert atmosphere

With titanium(IV) tetraethanolate; sodium tetrahydroborate; trimethylaluminum; sodium hydride; caesium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/c5cc05378a