anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

Base Information

Chemical Name:anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester
CAS No.:439090-04-7
Molecular Formula:C₂₂H₃₃NO₅
Molecular Weight:391.508
Hs Code.:

Synonyms:anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

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Chemical Property of anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

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Technology Process of anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

There total 6 articles about anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 98946-18-0
tert-Butyl 2,2,2-trichloroacetimidate

: 439090-02-5
anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid

: 439090-04-7
anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jm010242p

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 439090-04-7
anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / methanol / 12 h / 20 °C

2: 92 percent / CH₂Cl₂ / 15 h / 20 °C

With triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm010242p

Reference yield:

: 172324-67-3
3-benzyloxymethyl-cyclobutanone

: 439090-04-7
anti-1-[N-(tert-butoxycarbonyl)amino]-3-benzyloxymethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 16 percent / aq. (NH₄)2CO₃; aq. NH₄Cl / ethanol / 72 h / 60 °C

2: aq. NaOH / 12 h / 120 °C

3: Et₃N / methanol / 12 h / 20 °C

4: 92 percent / CH₂Cl₂ / 15 h / 20 °C

With sodium hydroxide; ammonium carbonate; ammonium chloride; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm010242p