(3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether

Base Information

Chemical Name:(3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether
CAS No.:220903-41-3
Molecular Formula:C₂₆H₃₃ClN₂O₄
Molecular Weight:473.012
Hs Code.:

Synonyms:(3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether

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Chemical Property of (3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether

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Technology Process of (3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether

There total 5 articles about (3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53713-77-2
3-benzyloxy-2-chloro-4-methoxy-benzaldehyde

: 220903-41-3
(3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / NaBH₄ / tetrahydrofuran; methanol / 5 h / 40 °C

2: 85 percent / PPh₃, CBr₄ / diethyl ether / 20 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 5 h

With sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1002/(sici)1521-3765(19990104)5:1<227::aid-chem227>3.3.co;2-o

Reference yield:

: 37687-57-3
2-chloro-3-hydroxy-4-methoxybenzaldehyde

: 220903-41-3
(3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 99 percent / NaBH₄ / tetrahydrofuran; methanol / 5 h / 40 °C

3: 85 percent / PPh₃, CBr₄ / diethyl ether / 20 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 5 h

With sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/(sici)1521-3765(19990104)5:1<227::aid-chem227>3.3.co;2-o

Reference yield:

: 100-39-0
benzyl bromide

: 220903-41-3
(3R,6S)-3-(3-benzyloxy-2-chloro-4-methoxy)benzyl-6-isopropyl-2,5-bisethyl lactim ether

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 99 percent / NaBH₄ / tetrahydrofuran; methanol / 5 h / 40 °C

3: 85 percent / PPh₃, CBr₄ / diethyl ether / 20 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 5 h

With sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/(sici)1521-3765(19990104)5:1<227::aid-chem227>3.3.co;2-o