10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione

Base Information

Chemical Name:10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione
CAS No.:1430798-61-0
Molecular Formula:C₃₁H₃₀N₂O₅
Molecular Weight:510.59
Hs Code.:

Synonyms:10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione

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Chemical Property of 10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione

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Technology Process of 10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione

There total 8 articles about 10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C₃₁H₃₂Cl₂N₂O₅: 1430798-60-9
C₃₁H₃₂Cl₂N₂O₅

10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione: 1430798-61-0
10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione

Guidance literature:: With potassium carbonate; XPhos; In isopropyl alcohol; at 85 ℃; for 14.5h; Inert atmosphere; Sealed tube;

Reference yield: 99.0%

: (2Z,2'Z)-3,3'-(4,6-dichloro-5-methoxy-1,3-phenylene)bis(N-(4-methoxybenzyl)but-2-enamide)

10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione: 1430798-61-0
10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione

Guidance literature:: With chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium carbonate; XPhos; In isopropyl alcohol; at 90 ℃; for 18h; Inert atmosphere;
DOI:10.1039/c9md00207c

Reference yield:

: 1984-65-2
2,6-dichloroanisole

10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione: 1430798-61-0
10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3.5 h / -78 - -65 °C / Inert atmosphere; Schlenk technique

1.2: 1 h / -75 - -65 °C / Inert atmosphere; Schlenk technique

2.1: Iodine monochloride / dichloromethane / 20 °C / Cooling with ice

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24.08 h / 80 °C / Inert atmosphere; Schlenk technique

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane; water / 3 h / 87 °C / Inert atmosphere

5.1: potassium carbonate; XPhos / isopropyl alcohol / 14.5 h / 85 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; Iodine monochloride; potassium carbonate; lithium diisopropyl amide; XPhos; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; 5.1: |Suzuki Coupling;