(-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

Base Information

Chemical Name:(-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one
CAS No.:321835-84-1
Molecular Formula:C₃₀H₄₂N₄O₄
Molecular Weight:522.688
Hs Code.:

Synonyms:(-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

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Chemical Property of (-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

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Technology Process of (-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

There total 9 articles about (-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 321835-83-0
(-)-(2S)-9-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-2-(4-methoxyphenyl)-1,5,9,14-tetraazabicyclo[12.3.1]octadecan-4-one

: 321835-84-1
(-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

Guidance literature:: With hydroxylamine hydrochloride; In hydrogenchloride; at 70 ℃; for 1h;
DOI:10.1002/1522-2675(20001108)83:11<2953::AID-HLCA2953>3.0.CO;2-I

Reference yield: 75.0%

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 151813-62-6
(-)-(S)-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

: 321835-84-1
(-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

Guidance literature:: (-)-(S)-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one; With formaldehyd;

(E)-3-(4-methoxyphenyl)acrylic acid; With 2-chloro-1-methyl-pyridinium iodide;

With hydroxylamine hydrochloride;
DOI:10.1002/1522-2675(20010711)84:7<2108::AID-HLCA2108>3.0.CO;2-G

Reference yield:

: 360059-20-7
(S)-3-Amino-3-(4-methoxy-phenyl)-propionic acid ethyl ester

: 321835-84-1
(-)-(8S)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / acetonitrile / Heating

2.1: 79 percent / Cu(OOCMe)2 / 24 h

3.1: 81 percent / Et₃N / CHCl₃

4.1: Cs₂CO₃ / dimethylformamide / 1.33 h / 20 - 60 °C

4.2: 87 percent / dimethylformamide / 30 h / 20 °C

5.1: 95 percent / electrochemical detosylation

6.1: HCHO

6.2: 2-chloro-N-methylpyridinium iodide

6.3: 75 percent / NH₂OH*HCl

With formaldehyd; copper diacetate; caesium carbonate; triethylamine; In chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/1522-2675(20010711)84:7<2108::AID-HLCA2108>3.0.CO;2-G