(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide

Base Information

Chemical Name:(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide
CAS No.:210642-63-0
Molecular Formula:C₂₁H₃₃NO₃Si
Molecular Weight:375.583
Hs Code.:

Synonyms:(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide

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Technology Process of (Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide

There total 7 articles about (Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95-55-6
2-amino-phenol

: 210642-63-0
(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / imidazole / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) Me₃Al / 1.) hexane, toluene, from 0 deg C to RT, 55 min, 2.) hexane, toluene, a) RT, 4 h, b) 60 deg C, 2 h

3: NaH / tetrahydrofuran / 3 h / Ambient temperature

4: n-Bu₄NBr, 1M aq. NaOH / CH₂Cl₂ / 12 h / Ambient temperature

5: 1.) NaH / 1.) THF, from 0 deg C to RT, 3 h, 2.) THF, RT, overnight

With 1H-imidazole; sodium hydroxide; tetrabutylammomium bromide; trimethylaluminum; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja980787h

Reference yield:

: 148802-00-0
(Z)-1-(tert-butyldimethylsilyloxy)-3-iodo-3-methylprop-2-ene

: 210642-63-0
(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / iPr₂NEt, Pd(PPh₃)4 / dimethylformamide / Ambient temperature

2: 1.) Me₃Al / 1.) hexane, toluene, from 0 deg C to RT, 55 min, 2.) hexane, toluene, a) RT, 4 h, b) 60 deg C, 2 h

3: NaH / tetrahydrofuran / 3 h / Ambient temperature

4: n-Bu₄NBr, 1M aq. NaOH / CH₂Cl₂ / 12 h / Ambient temperature

5: 1.) NaH / 1.) THF, from 0 deg C to RT, 3 h, 2.) THF, RT, overnight

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; trimethylaluminum; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja980787h

Reference yield:

: 210642-61-8
2-Triethylsilanyloxy-phenylamine

: 210642-63-0
(Z)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-but-2-enoic acid (2-allyloxy-phenyl)-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Me₃Al / 1.) hexane, toluene, from 0 deg C to RT, 55 min, 2.) hexane, toluene, a) RT, 4 h, b) 60 deg C, 2 h

2: NaH / tetrahydrofuran / 3 h / Ambient temperature

3: n-Bu₄NBr, 1M aq. NaOH / CH₂Cl₂ / 12 h / Ambient temperature

4: 1.) NaH / 1.) THF, from 0 deg C to RT, 3 h, 2.) THF, RT, overnight

With sodium hydroxide; tetrabutylammomium bromide; trimethylaluminum; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja980787h