[(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester

Base Information

• Chemical Name: [(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester
• CAS No.: 1262799-23-4
• Molecular Formula: C₁₇H₂₄FNO₄
• Molecular Weight: 325.38

Synonyms:[(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester

Chemical Property of [(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester

Chemical Property:

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Technology Process of [(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester

There total 1 articles about [(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + [(2R,3R,4S)-4-amino-4-(2-fluoro-phenyl)-2-methyl-tetrahydro-furan-3-yl]-methanol (1262799-51-8) → [(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester (1262799-23-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;

Reference yield: 76.0%

[(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester (1262799-23-4) → [(3S,4R,5R)-3-(2-fluoro-phenyl)-4-formyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester (1262803-67-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

[(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester (1262799-23-4) → C12H14FNO3

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In water; acetone; at 20 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

[(2R,3R,4S)-4-amino-4-(2-fluoro-phenyl)-2-methyl-tetrahydro-furan-3-yl]-methanol

Downstream raw materials:

(2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate

tert-butyl ((4aS,5R,7aS)-7a-(2-fluorophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

(4aS,5R,7aS)-2-amino-7a-(2-fluoro-5-nitrophenyl)-3,5-dimethyl-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one

tert-butyl ((4aS,5R,7aS)-7a-(2-fluoro-5-nitrophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)(N-tert-butoxycarbonyl)carbamate

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