Technology Process of (4aS,5R,7aS)-2-amino-7a-(2-fluoro-5-nitrophenyl)-3,5-dimethyl-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one
There total 5 articles about (4aS,5R,7aS)-2-amino-7a-(2-fluoro-5-nitrophenyl)-3,5-dimethyl-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl ((4aS,5R,7aS)-7a-(2-fluorophenyl)-3,5-dimethyl-4-oxo-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate;
With
nitric acid;
at 20 - 50 ℃;
With
sodium hydroxide;
In
water;
Ice-cooling;
With
ammonium chloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere
2.1: chromium(VI) oxide; sulfuric acid / water; acetone / 20 °C
3.1: sulfuric acid / methanol / 20 °C / Inert atmosphere; Reflux
4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere
5.1: nitric acid / 20 - 50 °C
5.2: Ice-cooling
With
chromium(VI) oxide; sulfuric acid; nitric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: chromium(VI) oxide; sulfuric acid / water; acetone / 20 °C
2.1: sulfuric acid / methanol / 20 °C / Inert atmosphere; Reflux
3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere
4.1: nitric acid / 20 - 50 °C
4.2: Ice-cooling
With
chromium(VI) oxide; sulfuric acid; nitric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
methanol; water; N,N-dimethyl-formamide; acetone;