(2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate

Base Information

Chemical Name:(2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate
CAS No.:1262799-25-6
Molecular Formula:C₁₃H₁₆FNO₃
Molecular Weight:253.273
Hs Code.:

Synonyms:(2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate

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Chemical Property of (2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate

Chemical Property:

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Technology Process of (2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate

There total 3 articles about (2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₁₂H₁₄FNO₃

: 1262799-25-6
(2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate

Guidance literature:: With sulfuric acid; In methanol; at 20 ℃; Inert atmosphere; Reflux;

Reference yield:

: 1262799-51-8
[(2R,3R,4S)-4-amino-4-(2-fluoro-phenyl)-2-methyl-tetrahydro-furan-3-yl]-methanol

: 1262799-25-6
(2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2: chromium(VI) oxide; sulfuric acid / water; acetone / 20 °C

3: sulfuric acid / methanol / 20 °C / Inert atmosphere; Reflux

With chromium(VI) oxide; sulfuric acid; triethylamine; In tetrahydrofuran; methanol; water; acetone;

Reference yield:

: 1262799-23-4
[(3S,4R,5R)-3-(2-fluoro-phenyl)-4-hydroxymethyl-5-methyl-tetrahydro-furan-3-yl]-carbamic acid tert-butylester

: 1262799-25-6
(2R,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-methyltetrahydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: chromium(VI) oxide; sulfuric acid / water; acetone / 20 °C

2: sulfuric acid / methanol / 20 °C / Inert atmosphere; Reflux

With chromium(VI) oxide; sulfuric acid; In methanol; water; acetone;