(2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

Base Information

Chemical Name:(2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal
CAS No.:225797-51-3
Molecular Formula:C₂₅H₂₆O₆
Molecular Weight:422.478
Hs Code.:

Synonyms:(2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

Suppliers and Price of (2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

There total 1 articles about (2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 7152-47-8
D-ribose diethyl dithioacetal

: 14470-28-1
mono-4-methoxytrityl chloride

: 225797-51-3
(2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

Guidance literature:: With silver nitrate; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)80342-1

Reference yield:

: 225797-51-3
(2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

: 117326-02-0
5-O-[(1,1-Dimethylethyl)dimethylsilyl]-2-O-[(phenylmethoxy)methyl]-β-D-ribofuranosyl-2,3,4-tris-O-(phenylmethyl)-D-ribitol

Guidance literature:: Multi-step reaction with 10 steps

1: sodium hydride / dimethylformamide

2: p-toluenesulfonic acid / methanol

3: 98 percent / pyridine / DMAP / CH₂Cl₂ / Ambient temperature

4: 1.) HgCl₂, CdCO₃, 2.) NaBH₃CN, further reducing agent and solvent / 1.) acetone-water, 2.) dimethoxyethane

5: 97 percent / silver perchlorate, 4-Angstroem molecular sieves / acetonitrile / -40 °C

6: 2.) pyridine

7: Bu₄NI, DMAP, diisopropylethylamine / tetrahydrofuran / 96 h / Ambient temperature

8: tetra-n-butylammonium fluoride

9: 96 percent / silver nitrate, DMAP / tetrahydrofuran

10: LiEt₃BH / tetrahydrofuran / 3 h / 25 °C

With pyridine; dmap; cadmium(II) carbonate; 4 A molecular sieve; tetrabutyl ammonium fluoride; silver perchlorate; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium triethylborohydride; sodium cyanoborohydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; mercury dichloride; dmap; silver nitrate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)80342-1

Reference yield:

: 225797-51-3
(2R,3R,4R)-2,3,4-Trihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-pentanal

: 117326-00-8
2,2-Dimethyl-propionic acid (2R,3S,4S)-2,3,4-tris-benzyloxy-5-((2R,3R,4R,5R)-3-benzyloxymethoxy-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yloxy)-pentyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydride / dimethylformamide

2: p-toluenesulfonic acid / methanol

3: 98 percent / pyridine / DMAP / CH₂Cl₂ / Ambient temperature

4: 1.) HgCl₂, CdCO₃, 2.) NaBH₃CN, further reducing agent and solvent / 1.) acetone-water, 2.) dimethoxyethane

5: 97 percent / silver perchlorate, 4-Angstroem molecular sieves / acetonitrile / -40 °C

6: 2.) pyridine

7: Bu₄NI, DMAP, diisopropylethylamine / tetrahydrofuran / 96 h / Ambient temperature

8: tetra-n-butylammonium fluoride

With pyridine; dmap; cadmium(II) carbonate; 4 A molecular sieve; tetrabutyl ammonium fluoride; silver perchlorate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; mercury dichloride; dmap; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)80342-1