(E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Base Information

Chemical Name:(E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide
CAS No.:1360538-15-3
Molecular Formula:C₁₈H₁₂F₃N₃OS
Molecular Weight:375.374
Hs Code.:

Synonyms:(E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide

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Chemical Property of (E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide

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Technology Process of (E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide

There total 3 articles about (E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2002-03-1
2-amino-5-phenyl-1,3,4-thiadiazole

: 16642-92-5,87212-84-8,2062-26-2
4-(trifluoromethyl)cinnamic acid

: 1360538-15-3
(E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Reflux;
DOI:10.1016/j.bmc.2011.12.057

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1360538-15-3
(E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; pyridine / 12 h / 80 - 90 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Reflux

With piperidine; pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmc.2011.12.057

Reference yield:

: 65-85-0,8013-63-6
benzoic acid

: 1360538-15-3
(E)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 6 h / 75 - 80 °C

1.2: 1 h / Reflux

1.3: pH 8 - 9 / Cooling with ice

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Reflux

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In dichloromethane;
DOI:10.1016/j.bmc.2011.12.057