1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one

Base Information

Chemical Name:1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one
CAS No.:146512-26-7
Molecular Formula:C₁₄H₉F₃N₄O₃
Molecular Weight:338.246
Hs Code.:

Synonyms:1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one

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Chemical Property of 1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one

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Technology Process of 1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one

There total 5 articles about 1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1792-60-5
2-amino-5-nitro-3-pyridinecarboxamide

: 146512-26-7
1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one

Guidance literature:: With zinc(II) chloride; In diethylene glycol dimethyl ether; at 120 ℃; for 7h;
DOI:10.1002/jhet.5570290629

Reference yield:

: 135795-55-0
2-chloro-3-chlorocarbonyl-5-nitropyridine

: 146512-26-7
1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2 h / Heating

2: 85 percent / anhydrous ammonia / methanol / 4 h / 80 - 100 °C / 7757.2 Torr

3: 43 percent / zinc chloride / bis-(2-methoxy-ethyl) ether / 7 h / 120 °C

With ammonia; zinc(II) chloride; In methanol; diethylene glycol dimethyl ether;
DOI:10.1002/jhet.5570290629

Reference yield:

: 1314901-45-5
1,2-dihydro-2-oxo-3-pyridinecarboxylic acid

: 146512-26-7
1,4-dihydro-6-nitro-2-(4-trifluoromethylphenyl)-3H-pyrido<2,3-d>pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / nitric acid, conc. sulfuric acid / 2 h / 60 °C

2: phosphorus oxychloride / chlorobenzene / 2 h / Heating

3: 2 h / Heating

4: 85 percent / anhydrous ammonia / methanol / 4 h / 80 - 100 °C / 7757.2 Torr

5: 43 percent / zinc chloride / bis-(2-methoxy-ethyl) ether / 7 h / 120 °C

With sulfuric acid; ammonia; nitric acid; zinc(II) chloride; trichlorophosphate; In methanol; diethylene glycol dimethyl ether; chlorobenzene;
DOI:10.1002/jhet.5570290629