135795-55-0

Basic information

• Product Name: 2-chloro-5-nitronicotinoyl chloride
• Synonyms: 2-chloro-5-nitronicotinoyl chloride
• CAS NO: 135795-55-0
• Molecular Formula: C₆H₂Cl₂N₂O₃
• Molecular Weight: 220.99768
• Mol File: 135795-55-0.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-5-nitronicotinoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-nitronicotinoyl chloride(135795-55-0)
• EPA Substance Registry System: 2-chloro-5-nitronicotinoyl chloride(135795-55-0)

Safety Data

• Hazardous Substances Data: 135795-55-0(Hazardous Substances Data)

Upstream product

• 10128-92-4 2-hydroxynicotinamide 
• 941083-49-4 C₆H₅N₃O₄ 
• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 21901-34-8 2-hydroxy-3-methyl-5-nitropyridine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 1314901-45-5 1,2-dihydro-2-oxo-3-pyridinecarboxylic acid 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 42959-38-6 3-carboxy-2-chloro-5-nitro pyridine 
• 6854-07-5 2-hydroxy-5-nitropyridine-3-carboxylic acid 

Downstream Products

• 151322-83-7 ethyl 2-chloro-5-nitro-3-pyridinecarboxylate 
• 31309-08-7 2-chloro-5-nitropyridine-3-carbonitrile 
• 690223-99-5 4-hydroxy-6-nitro-[1,8]naphthyridine-3-carbonitrile 
• 305370-84-7 4-chloro-6-nitro-[1.8]naphthyridine-3-carbonitrile 
• 60524-15-4 2-chloro-5-nitronicotinamide 
• 284686-32-4 2-chloro-N-[(2'-cyclopropylamino)-4'-methyl-3'-pyridyl]-8-nitro-3-pyridinecarboxamide 
• 134894-58-9 N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitro-3-pyridinecarboxamide 

Relevant articles and documents

New 2-Thiopyridines as potential candidates for killing both actively growing and dormant mycobacterium tuberculosis cells

From in vivo observations, a majority of M. tuberculosis cells in latently infected individuals are in a dormant and probably nonculturable state, display little metabolic activity, and are phenotypically resistant to antibiotics. Despite many attempts, no specific antimicrobials effective against latent tuberculosis have yet been found, partly because of a lack of reliable and adequate in vitro models for screening of drug candidates. We propose here a novel in vitro model of M. tuberculosis dormancy that meets the important criteria of latency, namely, nonculturability of cells, considerable reduction of metabolic activity, and significant phenotypic resistance to the first-line antibiotics rifampin and isoniazid. Using this model, we found a new group of 2-thiopyridine derivatives that had potent antibacterial activity against both actively growing and dormant M. tuberculosis cells. By means of the model of M. tuberculosis nonculturability, several new 2-thiopyridine derivatives were found to have potent antitubercular activity. The compounds are effective against both active and dormant M. tuberculosis cells. The bactericidal effects of compounds against dormant M. tuberculosis was confirmed by using three different in vitro models of tuberculosis dormancy. The model of nonculturability could be used as a reliable tool for screening drug candidates, and 2-thiopyridine derivatives may be regarded as prominent compounds for further development of new drugs for curing latent M. tuberculosis infection.

SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof.

PYRIDO-OXAZINONE DERIVATIVES AS TNAP INHIBITORS

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) : wherein R