C₂₅H₂₅F₃N₂O₂

Base Information

Chemical Name:C₂₅H₂₅F₃N₂O₂
CAS No.:1441055-34-0
Molecular Formula:C₂₅H₂₅F₃N₂O₂
Molecular Weight:442.481
Hs Code.:

C<sub>25</sub>H<sub>25</sub>F<sub>3</sub>N<sub>2</sub>O<sub>2</sub>

Synonyms:C₂₅H₂₅F₃N₂O₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₅H₂₅F₃N₂O₂

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Technology Process of C₂₅H₂₅F₃N₂O₂

There total 4 articles about C₂₅H₂₅F₃N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 123-51-3
i-Amyl alcohol

: 1441049-30-4
6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

: 1441055-34-0
C₂₅H₂₅F₃N₂O₂

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 0 - 20 ℃; for 2.33333h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01356

Reference yield:

: 619-41-0
4-(bromoacetyl)toluene

: 1441055-34-0
C₂₅H₂₅F₃N₂O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2.5 h / Reflux

1.2: 16 h / 20 °C

2.1: tetrahydrofuran / 0.28 h / 150 °C / Microwave irradiation

3.1: ammonium hydroxide / dimethyl sulfoxide / 20 °C

4.1: pyridine; dmap / dichloromethane / 2.83 h / 0 - 20 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; potassium hydroxide / water; 1,4-dioxane / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

6.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 2.33 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; potassium hydroxide; diethylazodicarboxylate; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; 2.1: |Wittig Olefination / 6.1: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.1c01356

Reference yield:

: 1441057-85-7
(Z)-3-(4-bromophenyl)-4,4,4-trifluoro-1-p-tolylbut-2-en-1-one

: 1441055-34-0
C₂₅H₂₅F₃N₂O₂

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / dimethyl sulfoxide / 20 °C

2: pyridine; dmap / dichloromethane / 2.83 h / 0 - 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; potassium hydroxide / water; 1,4-dioxane / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

4: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 2.33 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; potassium hydroxide; diethylazodicarboxylate; tert-butyl XPhos; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; 4: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.1c01356