4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol

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Chemical Name:4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol
CAS No.:1402149-82-9
Molecular Formula:C₃₄H₃₅N₅O₄S
Molecular Weight:609.749
Hs Code.:

Synonyms:4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol

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Chemical Property of 4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol

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Technology Process of 4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol

There total 6 articles about 4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1311269-31-4
(R)-4-((7-bromo-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

: 62-53-3
aniline

: 1402149-82-9
4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate; In tetrahydrofuran; at 100 ℃; for 8h; Schlenk technique; Inert atmosphere; Reflux;
DOI:10.1021/jm300624s

Reference yield:

: 4692-98-2
5-bromoisatoic anhydride

: 1402149-82-9
4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; dmap / Reflux; Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

3.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / tetrahydrofuran / 8 h / 100 °C / Schlenk technique; Inert atmosphere; Reflux

With pyridine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; trifluoroacetic acid; trifluoroacetic anhydride; johnphos; sodium t-butanolate; In tetrahydrofuran; toluene;
DOI:10.1021/jm300624s

Reference yield:

: 1311269-26-7
(3R)-7-bromo-3-[(4-hydroxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione

: 1402149-82-9
4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-7-(phenylamino)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

2.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / tetrahydrofuran / 8 h / 100 °C / Schlenk technique; Inert atmosphere; Reflux

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; trifluoroacetic acid; trifluoroacetic anhydride; johnphos; sodium t-butanolate; In tetrahydrofuran; toluene;
DOI:10.1021/jm300624s