Technology Process of methyl 4-[4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl]benzoate
There total 10 articles about methyl 4-[4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl]benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine;
In
isopropyl alcohol;
for 2h;
Heating;
DOI:10.1021/jm990063w
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 99 percent / H2SO4 / 16 h / Heating
2.1: 85 percent / Na / xylene / 2 h / 100 °C
3.1: 70 percent / aq. CrO3; AcOH / 3 h / 15 °C
4.1: NaOH / methanol / 48 h / Heating
4.2: 72 percent / H2SO4 / 6 h / Heating
5.1: 60 percent / DIBAL-H / CH2Cl2; toluene / 1 h / -78 °C
6.1: 89 percent / oxalyl chloride; dimethyl sulfoxide / CH2Cl2 / 0.25 h / -60 °C
7.1: diethyl ether / 0.5 h / 0 °C
8.1: 60 percent / (COCl)2; DMSO / CH2Cl2 / 0.25 h / -60 °C
9.1: 87 percent / copper(II) bromide / ethyl acetate; CHCl3 / 8 h / Heating
10.1: 52 percent / pyridine / propan-2-ol / 2 h / Heating
With
pyridine; chromium(VI) oxide; sodium hydroxide; oxalyl dichloride; sulfuric acid; sodium; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; copper(ll) bromide;
In
methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate; isopropyl alcohol; toluene; xylene;
1.1: Esterification / 2.1: Cyclization / 3.1: Oxidation / 4.1: Condensation / 4.2: Cyclization / 5.1: Reduction / 6.1: Swern oxidation / 7.1: Grignard reaction / 8.1: Swern oxidation / 9.1: Bromination / 10.1: cyclocondensation;
DOI:10.1021/jm990063w
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 85 percent / Na / xylene / 2 h / 100 °C
2.1: 70 percent / aq. CrO3; AcOH / 3 h / 15 °C
3.1: NaOH / methanol / 48 h / Heating
3.2: 72 percent / H2SO4 / 6 h / Heating
4.1: 60 percent / DIBAL-H / CH2Cl2; toluene / 1 h / -78 °C
5.1: 89 percent / oxalyl chloride; dimethyl sulfoxide / CH2Cl2 / 0.25 h / -60 °C
6.1: diethyl ether / 0.5 h / 0 °C
7.1: 60 percent / (COCl)2; DMSO / CH2Cl2 / 0.25 h / -60 °C
8.1: 87 percent / copper(II) bromide / ethyl acetate; CHCl3 / 8 h / Heating
9.1: 52 percent / pyridine / propan-2-ol / 2 h / Heating
With
pyridine; chromium(VI) oxide; sodium hydroxide; oxalyl dichloride; sodium; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; copper(ll) bromide;
In
methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate; isopropyl alcohol; toluene; xylene;
1.1: Cyclization / 2.1: Oxidation / 3.1: Condensation / 3.2: Cyclization / 4.1: Reduction / 5.1: Swern oxidation / 6.1: Grignard reaction / 7.1: Swern oxidation / 8.1: Bromination / 9.1: cyclocondensation;
DOI:10.1021/jm990063w
