80393-38-0

Basic information

• Product Name: Methyl 4-carbaMothioylbenzoate
• Synonyms: Methyl 4-carbaMothioylbenzoate;methyl 4-(aminothioxomethyl)benzoate;4-Thiocarbamoyl-benzoic acid methyl ester
• CAS NO: 80393-38-0
• Molecular Formula: C₉H₉NO₂S
• Molecular Weight: 195.23826
• Mol File: 80393-38-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 191-192 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 327.9±44.0 °C(Predicted)
• Appearance: /
• Density: 1.268±0.06 g/cm3(Predicted)
• PKA: 12.13±0.29(Predicted)
• CAS DataBase Reference: Methyl 4-carbaMothioylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-carbaMothioylbenzoate(80393-38-0)
• EPA Substance Registry System: Methyl 4-carbaMothioylbenzoate(80393-38-0)

Safety Data

• Hazardous Substances Data: 80393-38-0(Hazardous Substances Data)

Upstream product

• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 507-09-5 tiolacetic acid 
• 6757-31-9 methyl-4-carbamoylbenzoate 

Downstream Products

• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 247088-31-9 methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide 
• 247088-29-5 methyl 4-[(4-phenyl)thiazol-2-yl]benzoate 
• 1314243-56-5 C₁₅H₁₃NO₃S 
• 325769-18-4 methyl 4-[4-(3-methylphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]benzoate 
• 100063-18-1 4-(4-methyl-thiazol-2-yl)-benzoic acid methyl ester 
• 261162-98-5 methyl 4-[4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl]benzoate 

Relevant articles and documents

Synthesis of imidazo[1,2-: C] thiazoles through Pd-catalyzed bicyclization of tert-butyl isonitrile with thioamides

Building new biological molecules is challenging. Herein, imidazo[1,2-c]thiazoles were synthesized as a new class of heterobicyclic analogs through Pd-catalyzed cascade bicyclization from isonitriles with thioamides. The bicyclic scaffolds were constructed by inserting three molecules of isonitrile into two molecules of thioamide and then cyclizing them in a one-pot procedure. In vitro antitumor studies of these new compounds were conducted by using the MTT assay, and compound 3c showed excellent inhibitory effects against HepG2 at 7.06 ± 0.68 μM.

SUBSTITUTED BENZAMIDES AND THEIR USES

Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use.

A mild and versatile synthesis of thioamides

Aliphatic and aromatic nitriles react with thioacetic acid in the presence of calcium hydride to give the corresponding thioamides in good to excellent yields. The examples studied include haloaryl nitriles in which the halogen is facile towards SNAr reactions under other conditions. Georg Thieme Verlag Stuttgart.