ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate

Base Information

Chemical Name:ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate
CAS No.:129277-08-3
Molecular Formula:C₁₃H₁₈O₅S
Molecular Weight:286.349
Hs Code.:
European Community (EC) Number:603-326-7
DSSTox Substance ID:DTXSID201229231

Synonyms:129277-08-3;ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate;Ethyl (alphaR)-alpha-[(methylsulfonyl)oxy]benzenebutanoate;QKQLJQXSPKYPFD-GFCCVEGCSA-N;DTXSID201229231

Suppliers and Price of ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:286.08749484
Heavy Atom Count:19
Complexity:365

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(CCC1=CC=CC=C1)OS(=O)(=O)C
Isomeric SMILES:CCOC(=O)[C@@H](CCC1=CC=CC=C1)OS(=O)(=O)C
Uses Ethyl (αR)-α-[(Methylsulfonyl)oxy]benzenebutanoate is used in the preparation of Imidapril Hydrochloride(I275040) which is an angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

Technology Process of ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate

There total 1 articles about ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 90315-82-5
ethyl (R)-2-hydroxy-4-phenylbutyrate

: 124-63-0
methanesulfonyl chloride

: 129277-08-3
ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/cmdc.201900028

Reference yield: 50.0%

: 142-08-5,1199357-22-6
2-Pyridone

: 129277-08-3
ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate

: (S)-ethyl 2-(2-oxopyridin-1(2H)-yl)-4-phenylbutanoate

Guidance literature:: 2-Pyridone; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

ethyl (R)-2-methylsulfonyloxy-4-phenylbutyrate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/cmdc.201900028