(S)-2-Amino-N¹-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide

Base Information

• Chemical Name: (S)-2-Amino-N¹-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide
• CAS No.: 143224-66-2
• Molecular Formula: C₂₃H₃₉N₅O₄
• Molecular Weight: 449.594

Synonyms:(S)-2-Amino-N¹-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide

Chemical Property of (S)-2-Amino-N¹-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-N¹-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide

There total 6 articles about (S)-2-Amino-N¹-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(S)-1-[(1S,2R)-1-Benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propylcarbamoyl]-2-carbamoyl-ethyl}-carbamic acid benzyl ester (143224-65-1) → (S)-2-Amino-N1-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide (143224-66-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00054a014

Reference yield:

N-benzyloxycarbonyl-3(S)-amino-1,2(S)epoxy-4-phenylbutane (128018-44-0) → (S)-2-Amino-N1-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide (143224-66-2)

Guidance literature:

Multi-step reaction with 5 steps

1: propan-2-ol / Heating

2: CH₂Cl₂ / Ambient temperature

3: H₂ / Pd(C) / ethanol

4: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole hydrate (HOBT) / dimethylformamide

5: H₂ / Pd(C) / ethanol

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm00054a014

Reference yield:

(S)-benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate (26049-94-5) → (S)-2-Amino-N1-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide (143224-66-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 43 percent / NaBH₄ / methanol; tetrahydrofuran

2: 90 percent / KOH / ethanol

3: propan-2-ol / Heating

4: CH₂Cl₂ / Ambient temperature

5: H₂ / Pd(C) / ethanol

6: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole hydrate (HOBT) / dimethylformamide

7: H₂ / Pd(C) / ethanol

With potassium hydroxide; sodium tetrahydroborate; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm00054a014

upstream raw materials:

{(S)-1-[(1S,2R)-1-Benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propylcarbamoyl]-2-carbamoyl-ethyl}-carbamic acid benzyl ester

N-benzyloxycarbonyl-3(S)-amino-1,2(S)epoxy-4-phenylbutane

(S)-benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate

N-benzyloxycarbonyl-3(S)-amino-1-chloro-4-phenyl-2(S)-butanol

Downstream raw materials:

Telinavir

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 143224-66-2 (S)-2-Amino-N¹-[(1S,2R)-1-benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-succinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send