(Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione

Base Information

Chemical Name:(Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione
CAS No.:1438409-40-5
Molecular Formula:C₁₈H₁₆N₂O₃S
Molecular Weight:340.403
Hs Code.:

Synonyms:(Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione

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Chemical Property of (Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione

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Technology Process of (Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione

There total 3 articles about (Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

: 6959-47-3
2-chloromethylpyridine hydrochloride

: (Z)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione

: 1438409-40-5
(Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione

Guidance literature:: (Z)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione; With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

2-chloromethylpyridine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/c3ob40199e

Reference yield: 97.5%

: 1438409-40-5
(Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h; Inert atmosphere;

In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 10031-82-0
4-ethoxybenzaldehyde

: 1438409-40-5
(Z)-5-(4-ethoxybenzylidene)-3-(pyridin-2-ylmethyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine / ethanol / 24 h / 20 - 75 °C

2.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 20 °C

With piperidine; potassium carbonate; sodium iodide; In ethanol; N,N-dimethyl-formamide; 1.1: |Knoevenagel Condensation;
DOI:10.1039/c3ob40199e