4-Ethoxybenzaldehyde

Base Information

• Chemical Name: 4-Ethoxybenzaldehyde
• CAS No.: 10031-82-0
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Hs Code.: 29124990
• European Community (EC) Number: 233-093-3
• NSC Number: 406709
• UNII: GOW1H0F49A
• DSSTox Substance ID: DTXSID7022251
• Nikkaji Number: J38.403H
• Wikidata: Q27279208
• Metabolomics Workbench ID: 46317
• Mol file: 10031-82-0.mol

Synonyms:4-ETHOXYBENZALDEHYDE;10031-82-0;p-Ethoxybenzaldehyde;Benzaldehyde, 4-ethoxy-;Ethoxybenzaldehyde;Benzaldehyde, p-ethoxy-;Homoanisaldehyde;MFCD00003388;Ethoxybenzaldehyde, p-;FEMA No. 2413;4-(ethyloxy)benzaldehyde;4-ethoxy-benzaldehyde;EINECS 233-093-3;UNII-GOW1H0F49A;NSC 406709;BRN 0386863;GOW1H0F49A;AI3-05684;NSC-406709;4-08-00-00254 (Beilstein Handbook Reference);NSC406709;p-Ethoxy benzaldehyde;p-Ethoxy-Benzaldehyde;para-ethoxybenzaldehyde;4 - ethoxybenzaldehyde;4-Ethoxybenzaldehyde, 99%;SCHEMBL342467;DTXSID7022251;FEMA 2413;CHEBI:167817;P-ETHOXYBENZALDEHYDE [FHFI];4-ETHOXYBENZALDEHYDE [INCI];4-Ethoxybenzaldehyde, >=99%, FG;BBL027437;STL282399;AKOS000119731;CS-W018144;LS-2711;AS-13462;SY009945;AM20050559;E0042;FT-0618379;EN300-16097;D71244;A800097;W-108968;Q27279208;Z53833126;F0913-0490

Chemical Property of 4-Ethoxybenzaldehyde

Chemical Property:

• Appearance/Colour: clear yellow to light brown liquid
• Vapor Pressure: 0.0249mmHg at 25°C
• Melting Point: 13-14 °C(lit.)
• Refractive Index: n20/D 1.559(lit.)
• Boiling Point: 249 °C at 760 mmHg
• Flash Point: 112.6 °C
• PSA: 26.30000
• Density: 1.06 g/cm³
• LogP: 1.89780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 150.068079557
• Heavy Atom Count: 11
• Complexity: 115

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Ethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)C=O
• Description: 4-Ethoxybenzaldehyde is a flavoring ingredient. 4-Ethoxybenzaldehyde can be used as an anti-inflammatory and prostaglandin E2 suppressor. It has also been indicated that it is useful in reducing facial erythema.
• Uses: 4-Ethoxybenzaldehyde was used as an anti-inflammatory and prostaglandin E2 suppressor in skin lightening agents.

Technology Process of 4-Ethoxybenzaldehyde

There total 40 articles about 4-Ethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

diethyl sulfate (64-67-5) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-ethoxybenzaldehyde (10031-82-0)

Guidance literature:

With potassium carbonate; In acetonitrile; for 0.5h; Heating;

DOI:10.1021/jm970815r

Reference yield: 96.0%

4-ethoxybenzyl alcohol (6214-44-4) → 4-ethoxybenzaldehyde (10031-82-0)

Guidance literature:

With 4-methyl-morpholine; chromium(VI) oxide; hydrogenchloride; In diethyl ether; chloroform; at 65 ℃; for 0.1h; microwave irradiation;

DOI:10.1080/00397910802219502

Reference yield: 92.0%

4-Aethoxy-benzaldehyd-2.4-dinitro-phenylhydrazon (1166-15-0) → 4-ethoxybenzaldehyde (10031-82-0)

Guidance literature:

With aluminum oxide; HMTAB; In toluene; for 0.25h; Heating;

DOI:10.1002/jccs.200700020

upstream raw materials:

ethanol

sodium ethanolate

4-formyl-tri-N-methyl-anilinium; chloride

hexamethylenetetramine

Downstream raw materials:

(E)-N’-(4'-ethoxybenzylidene)isonicotinohydrazide

2-(4-ethoxyphenyl)indan-1,3-dione

4-Ethoxy-β,β'-dibromostyrene

Refernces

• 1、 Sharma, Vinay S.,Patel. "Tuning the mesomorphic properties of nonisomeric chalconyl-ester bases homologous series: The effect of tail group". . p. 40 - 51. Retrieved 2017.
• 2、 Tong, Xinli,Sun, Yongfa,Yan, Yongtao,Luo, Xuan,Liu, Jinbiao,Wu, Zhidong. "Transition metal-free catalytic oxidation of aromatic alcohols with molecular oxygen in the presence of a catalytic amount of N-bromosuccinimide". . p. 1 - 6. Retrieved 2014.
• 3、 Li, Wen-Shan,Liu, Lilian Kao. "A Convenient Oxidation of Benzylic Methyl, Methylene, and Methine Groups with Potassium Permanganate/Triethylamine Reagent". . p. 293 - 295. Retrieved 1989.
• 4、 Spletstoser, Jared T.,White, Jonathan M.,Tunoori, Ashok Rao,Georg, Gunda I.. "Mild and selective hydrozirconation of amides to aldehydes using Cp 2Zr(H)Cl: Scope and mechanistic insight". . p. 3408 - 3419. Retrieved 2007.
• 5、 Bhola,Maheta,Bhoya. "Mesomorphism of Novel Symmetric Dimers with Changing Alkoxy Terminal End Group". . p. 129 - 138. Retrieved 2015.
• 6、 Bhola,Bhoya. "Mesomorphism dependence on heterocyclic end group". . p. 11 - 19. Retrieved 2016.
• 7、 Sharma, Vinay S.,Patel. "Mesomorphism dependence on halogenated chalconyl esters in terms of molecular flexibility/rigidity". . p. 80 - 90. Retrieved 2016.
• 8、 Awad, Adil A.,Omarali, Al-Ameen Bariz,Al-Karawi, Ahmed Jasim M.,Al-Qaisi, Zyad Hussein J.,Majeed, Samer Ghanim. "Mesomorphism behaviour and photoluminescent properties of new asymmetrical 1,2-di(4-alkoxybenzylidene) hydrazines". . p. 67 - 77. Retrieved 2019.
• 9、 Dorofeenko et al.. "-". . . Retrieved 1971.
• 10、 Sharma, Vinay S.,Patel. "Synthesis, characterization, and mesomorphic investigation of vinyl ester-substituted chalcones and effect of lateral ?NO2 and ?OCH3 group". . p. 241 - 251. Retrieved 2017.