1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Base Information

• Chemical Name: 1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
• CAS No.: 113696-44-9
• Molecular Formula: C₂₃H₃₀Cl₂N₂O₄*2ClH
• Molecular Weight: 542.33

Synonyms:1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Chemical Property of 1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Chemical Property:

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Technology Process of 1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

There total 3 articles about 1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride (113696-41-6) → 1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (113696-44-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.35.2774

Reference yield:

trimetazidine dihydrochloride (13171-25-0,127881-54-3) → 1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (113696-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / ethanol / 6 h / Heating

2: 81 percent / sodium borohydride (NaBH₄) / methanol / 0.5 h / Ambient temperature

With sodium tetrahydroborate; In methanol; ethanol;

DOI:10.1248/cpb.35.2774

Reference yield:

3',4'-dichloroacetophenone (2642-63-9) → 1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (113696-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / ethanol / 6 h / Heating

2: 81 percent / sodium borohydride (NaBH₄) / methanol / 0.5 h / Ambient temperature

With sodium tetrahydroborate; In methanol; ethanol;

DOI:10.1248/cpb.35.2774

upstream raw materials:

1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

trimetazidine dihydrochloride

3',4'-dichloroacetophenone

Downstream raw materials:

1-(3,4-dichlorocinnamyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

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