1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

Base Information

Chemical Name:1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride
CAS No.:113696-41-6
Molecular Formula:C₂₃H₂₈Cl₂N₂O₄*2ClH
Molecular Weight:540.314
Hs Code.:

Synonyms:1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

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Chemical Property of 1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

Chemical Property:

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Technology Process of 1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

There total 1 articles about 1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 13171-25-0,127881-54-3
trimetazidine dihydrochloride

: 2642-63-9
3',4'-dichloroacetophenone

: 113696-41-6
1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

Guidance literature:: In ethanol; for 6h; Heating;
DOI:10.1248/cpb.35.2774

Reference yield: 81.0%

: 113696-41-6
1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

: 113696-44-9
1-<3-(3,4-dichlorophenyl)-3-hydroxypropyl>-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.35.2774

Reference yield:

: 113696-41-6
1-(3,4-Dichloro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

: 113696-51-8
1-(3,4-dichlorocinnamyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / sodium borohydride (NaBH₄) / methanol / 0.5 h / Ambient temperature

2: 10 percent / phosphoric acid (50percent) / 7 h / 90 °C

With sodium tetrahydroborate; phosphoric acid; In methanol;
DOI:10.1248/cpb.35.2774