(3'-O-Acetylthymidin-5'-O-yl)(2-cyanoethoxy)[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-O-yl]phosphane

Base Information

Chemical Name:(3'-O-Acetylthymidin-5'-O-yl)(2-cyanoethoxy)[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-O-yl]phosphane
CAS No.:202719-41-3
Molecular Formula:C₄₆H₅₀N₅O₁₄P
Molecular Weight:927.902
Hs Code.:

Synonyms:(3'-O-Acetylthymidin-5'-O-yl)(2-cyanoethoxy)[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-O-yl]phosphane

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Chemical Property of (3'-O-Acetylthymidin-5'-O-yl)(2-cyanoethoxy)[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-O-yl]phosphane

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Technology Process of (3'-O-Acetylthymidin-5'-O-yl)(2-cyanoethoxy)[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-O-yl]phosphane

There total 2 articles about (3'-O-Acetylthymidin-5'-O-yl)(2-cyanoethoxy)[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-O-yl]phosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 98796-51-1
5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

: 21090-30-2
3'-O-acetylthymidine

: 202719-41-3
(3'-O-Acetylthymidin-5'-O-yl)(2-cyanoethoxy)[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-O-yl]phosphane

Guidance literature:: With 1H-tetrazole; In tetrahydrofuran; for 2h; Ambient temperature;

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 202719-41-3
(3'-O-Acetylthymidin-5'-O-yl)(2-cyanoethoxy)[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-O-yl]phosphane

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / (i-Pr)2NEt, tetrazole / CH₂Cl₂ / 16 h / Ambient temperature

2: 87 percent / tetrazole / tetrahydrofuran / 2 h / Ambient temperature

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;