1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

Base Information

Chemical Name:1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole
CAS No.:193225-65-9
Molecular Formula:C₂₅H₂₂ClN₃O₆
Molecular Weight:495.919
Hs Code.:

1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benz<e>indole

Synonyms:1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

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Chemical Property of 1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

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Technology Process of 1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

There total 3 articles about 1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1333242-48-0
(5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 1333242-23-1
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

: 193225-65-9
1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 193225-63-7
3-(tert-butoxycarbonyl)-1-(hydroxymethyl)-5-nitro-1,2-dihydro-3H-benzindole

: 1333242-23-1
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

: 193225-65-9
1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 1333242-46-8
tert-butyl 1-(tosyloxymethyl)-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

: 1333242-23-1
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

: 193225-65-9
1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.06.073