Technology Process of 4-(4-butoxycyclohexenyl)-2,3-difluorophenyl boronic acid
There total 5 articles about 4-(4-butoxycyclohexenyl)-2,3-difluorophenyl boronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-butoxy-1-(2,3-difluorphenyl)-cyclohex-1-ene;
With
sec.-butyllithium;
In
tetrahydrofuran; hexane; cyclohexane;
at -74 - -70 ℃;
for 2h;
Inert atmosphere;
With
Trimethyl borate;
In
tetrahydrofuran; hexane; cyclohexane;
at -74 - -65 ℃;
for 8h;
With
hydrogenchloride;
In
tetrahydrofuran; hexane; cyclohexane; water;
at 25 ℃;
Cooling with ice;
- Guidance literature:
-
4-butoxy-1-(2,3-difluorphenyl)-cyclohex-1-ene;
With
sec.-butyllithium;
In
tetrahydrofuran; hexane; cyclohexane;
at -74 - -70 ℃;
Inert atmosphere;
Trimethyl borate;
In
tetrahydrofuran; hexane; cyclohexane;
at -74 - 25 ℃;
Inert atmosphere;
With
hydrogenchloride; water;
In
tetrahydrofuran; hexane; cyclohexane;
Inert atmosphere;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sec.-butyllithium / cyclohexane; hexane; tetrahydrofuran / 2 h / -74 - -70 °C / Inert atmosphere
1.2: 8 h / -75 - -70 °C / Inert atmosphere
1.3: 25 °C
2.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux
3.1: sec.-butyllithium / cyclohexane; hexane; tetrahydrofuran / 2 h / -74 - -70 °C / Inert atmosphere
3.2: 8 h / -74 - -65 °C
3.3: 25 °C / Cooling with ice
With
sec.-butyllithium; toluene-4-sulfonic acid;
In
tetrahydrofuran; hexane; cyclohexane; toluene;
