1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Base Information

Chemical Name:1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene
CAS No.:1344700-55-5
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

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Chemical Property of 1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

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Technology Process of 1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

There total 11 articles about 1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1344700-54-4
N-[1-(4-ethynylphenyl)ethyl]cyclopropylamine

: 1344700-02-2
1-iodo-4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}benzene

: 1344700-55-5
1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In chloroform; at 20 ℃; for 2h;

Reference yield:

: 13329-40-3
4-Iodoacetophenone

: 1344700-55-5
1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium tris(acetoxy)borohydride / chloroform / 24 h / 20 °C / Inert atmosphere

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / chloroform / 24 h / 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / chloroform / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; In methanol; chloroform;

Reference yield:

: 1157231-97-4
N-[1-(4-iodophenyl)ethyl]cyclopropylamine

: 1344700-55-5
1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / chloroform / 24 h / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / chloroform / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In methanol; chloroform;