tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

Base Information

Chemical Name:tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate
CAS No.:1266161-32-3
Molecular Formula:C₃₀H₂₆FN₃O₃
Molecular Weight:495.553
Hs Code.:

Synonyms:tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

Suppliers and Price of tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

There total 6 articles about tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1266161-23-2
2-chloro-3-fluoro-5-(4-phenoxyphenyl)isonicotnonitrile

: 199609-62-6
(3-{[(tert-butoxycarbonyl)amino]methyl}phenyl)boronic acid

: 1266161-32-3
tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

Guidance literature:: With potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; at 100 ℃; for 2.5h; Inert atmosphere; Sealed tube;

Reference yield:

: 153463-65-1
3,5-dichloropyridine-4-carbonitrile

: 1266161-32-3
tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 20 h / Inert atmosphere; Sealed tube; Reflux

2.1: potassium fluoride / dimethyl sulfoxide / 240 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

4.1: trichlorophosphate / 1.5 h / 100 °C

4.2: 0 °C

5.1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 2.5 h / 100 °C / Inert atmosphere; Sealed tube

With potassium fluoride; potassium phosphate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 5.1: Suzuki Coupling;

Reference yield:

: 51067-38-0
4-phenoxyphenylboronic acid

: 1266161-32-3
tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 20 h / Inert atmosphere; Sealed tube; Reflux

2.1: potassium fluoride / dimethyl sulfoxide / 240 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

4.1: trichlorophosphate / 1.5 h / 100 °C

4.2: 0 °C

5.1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 2.5 h / 100 °C / Inert atmosphere; Sealed tube

With potassium fluoride; potassium phosphate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 5.1: Suzuki Coupling;