N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide

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Chemical Name:N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide
CAS No.:1266157-20-3
Molecular Formula:C₂₇H₂₃N₅O₂
Molecular Weight:449.512
Hs Code.:

Synonyms:N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide

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Chemical Property of N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide

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Technology Process of N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide

There total 9 articles about N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266161-35-6
N-(3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzyl)acetamide

: 1266157-20-3
N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide

Guidance literature:: With hydrazine; In water; butan-1-ol; at 120 ℃; for 15h; Sealed tube;

Reference yield:

: 153463-65-1
3,5-dichloropyridine-4-carbonitrile

: 1266157-20-3
N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 20 h / Inert atmosphere; Sealed tube; Reflux

2.1: potassium fluoride / dimethyl sulfoxide / 240 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

4.1: trichlorophosphate / 1.5 h / 100 °C

4.2: 0 °C

5.1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 2.5 h / 100 °C / Inert atmosphere; Sealed tube

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

8.1: hydrazine / butan-1-ol; water / 15 h / 120 °C / Sealed tube

With hydrogenchloride; potassium fluoride; potassium phosphate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; hydrazine; trichlorophosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; butan-1-ol; 5.1: Suzuki Coupling;

Reference yield:

: 51067-38-0
4-phenoxyphenylboronic acid

: 1266157-20-3
N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 20 h / Inert atmosphere; Sealed tube; Reflux

2.1: potassium fluoride / dimethyl sulfoxide / 240 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

4.1: trichlorophosphate / 1.5 h / 100 °C

4.2: 0 °C

5.1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 2.5 h / 100 °C / Inert atmosphere; Sealed tube

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

8.1: hydrazine / butan-1-ol; water / 15 h / 120 °C / Sealed tube

With hydrogenchloride; potassium fluoride; potassium phosphate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; hydrazine; trichlorophosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; butan-1-ol; 5.1: Suzuki Coupling;