4'-FluoroBiphenyl-4-carBoxylicacidethylester

Base Information

• Chemical Name: 4'-FluoroBiphenyl-4-carBoxylicacidethylester
• CAS No.: 10540-36-0
• Molecular Formula: C15H13 F O2
• Molecular Weight: 244.265
• Hs Code.: 2916399090
• Mol file: 10540-36-0.mol

Synonyms:4-Biphenylcarboxylicacid, 4'-fluoro-, ethyl ester (7CI,8CI); 4'-Fluorobiphenyl-4-carboxylic acidethyl ester

Chemical Property of 4'-FluoroBiphenyl-4-carBoxylicacidethylester

Chemical Property:

• Melting Point: 64.6-65.4℃
• Boiling Point: 349.6°Cat760mmHg
• Flash Point: 159.7°C
• PSA: 26.30000
• Density: 1.145g/cm³
• LogP: 3.66940

Purity/Quality:

98%,99%, ^*data from raw suppliers

4'-Fluorobiphenyl-4-carboxylicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-FluoroBiphenyl-4-carBoxylicacidethylester

There total 19 articles about 4'-FluoroBiphenyl-4-carBoxylicacidethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-aminoethylbenzoate (94-09-7) + potassim 4-fluorophenyltrifluoroborate → 4'-fluorobiphenyl-4-carboxylic acid ethyl ester (10540-36-0)

Guidance literature:

p-aminoethylbenzoate; With tetrafluoroboric acid; sodium nitrite; In water; at 0 - 5 ℃; for 0.5h;

potassim 4-fluorophenyltrifluoroborate; palladium diacetate; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 95.0%

Ethyl 4-bromobenzoate (5798-75-4) + 4-fluoroboronic acid (1765-93-1) → 4'-fluorobiphenyl-4-carboxylic acid ethyl ester (10540-36-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; at 20 ℃; for 0.25h;

DOI:10.1021/jm0507532

Reference yield: 95.0%

4-iodobenzoic acid ethyl ester (51934-41-9) + 4-fluoroboronic acid (1765-93-1) → 4'-fluorobiphenyl-4-carboxylic acid ethyl ester (10540-36-0)

Guidance literature:

With potassium carbonate; In ethanol; water; at 60 ℃; for 0.5h;

DOI:10.1016/j.catcom.2013.06.006

upstream raw materials:

4-fluoroboronic acid

p-carboethoxybenzenediazonium tetrafluoroborate

p-aminoethylbenzoate

Ethyl 4-bromobenzoate

Downstream raw materials:

4'-fluoro-biphenyl-4-carboxylic acid

4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide

Refernces

• 1、 Petros, Andrew M.,Dinges, Jurgen,Augeri, David J.,Baumeister, Steven A.,Betebenner, David A.,Bures, Mark G.,Elmore, Steven W.,Hajduk, Philip J.,Joseph, Mary K.,Landis, Shelley K.,Nettesheim, David G.,Rosenberg, Saul H.,Shen, Wang,Thomas, Sheela,Wang, Xilu,Zanze, Irini,Zhang, Haichao,Fesik, Stephen W.. "Discovery of a potent inhibitor of the antiapoptotic protein Bcl-X L from NMR and parallel synthesis". . p. 656 - 663. Retrieved 2006.
• 2、 Delaney, Connor P.,Kassel, Vincent M.,Denmark, Scott E.. "Potassium trimethylsilanolate enables rapid, homogeneous suzuki-miyaura cross-coupling of boronic esters". . p. 73 - 80. Retrieved 2019/12/24.
• 3、 Lian, Chang,Yue, Guanglu,Zhang, Haonan,Wei, Liyan,Liu, Danyang,Liu, Sichen,Fang, Huayi,Qiu, Di. "Synthesis of arylstannanes by palladium-catalyzed desulfitative coupling reaction of sodium arylsulfinates with distannanes". supporting information. p. 4019 - 4023. Retrieved 2018/10/04.